| Catalog number: | GENTAUR-58be5e48536a4 |
|---|---|
| Price: | 332 € |
| Supplier: | Bioss Primary Conjugated Antibodies. |
| Product name: | Anti-Claudin 1 (Polyclonal), ALEXA Fluor 594 |
| Quantity: | 100ul |
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| Type: | Conjugated Primary Antibody |
|---|---|
| Conjugated with: | 594, ALEXA FLUOR® |
| Host organism: | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: | Claudin 1 |
| Specificity: | This antibody reacts specifically with Claudin 1 |
| Modification: | No modification has been applied to this antibody |
| Modification site: | None |
| Clonality: | Polyclonal Antibody |
| Clone: | Polyclonal Antibodies |
| Concentration: | 1ug per 1ul |
| Subcellular locations: | Cytoplasm |
| Antigen Source: | KLH conjugated synthetic peptide derived from mouse Claudin 1 |
| Gene ID: | 12737 |
| Swiss Prot: | O88551 |
| Applications: | IF(IHC-P) |
| Applications with corresponding dilutions: | IF(IHC-P)(1:50-200) |
| Cross reactive species: | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: | CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin, Often, Required for normal water homeostasis and to prevent excessive water loss through the skin, While some claudin family members play essential roles in the formation of impermeable barriers, and this determines the overall permeability, others mediate the permeability to ions and small molecules, probably via an indirect effect on the expression levels of other proteins, several claudin family members are coexpressed and interact with each other, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions, Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia |
| Purification method: | Purified by Protein A |
| Storage: | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: | 590nm/617nm |
| Synonyms: | SEMP1 ILVASC |
| Also known as: | Claudin 1 Polyclonal Antibody |
| Other name: | Anti-Claudin 1 Polyclonal |
| Advisory: | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: | For facs or microscopy Alexa 1 conjugate |
| Conjugation: | Alexa Fluor |
| Group: | Polyclonals and antibodies |
| About: | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: | Claudin 1 |
| Short name: | Anti-Claudin 1 (Polyclonal) Fluor 594 |
| Technique: | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label: | ALEXA |
| Alternative name: | ALEXA Fluor 594, antibody to-Claudin 1 (polyclonal) |
| Alternative technique: | polyclonals |
| Identity: | 2032 |
| Gene: | CLDN1 | More about : CLDN1 |
| Long gene name: | claudin 1 |
| Synonyms name: | senescence-associated epithelial membrane protein 1 |
| Locus: | 3q28 |
| Discovery year: | 1998-11-19 |
| GenBank acession: | AF101051 |
| Entrez gene record: | 9076 |
| Pubmed identfication: | 10828592 9892664 |
| RefSeq identity: | NM_021101 |
| Classification: | Claudins |
| Havana BLAST/BLAT: | OTTHUMG00000156214 |
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