| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Claudin 22 |
| Specificity: |
This antibody reacts specifically with Claudin 22 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Claudin 22 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Claudin expression is often highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions, Claudin-22, Claudins, Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues, It is suggested that the claudin family of proteins regulate transport through tight junctions via differential discrimination for solute size and charge, also known as CLDN22, is a 220 amino acid member of the claudin family that participates in tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity, make up tight junction strands, which consist of four transmembrane domains and two extracellular loops, The claudin superfamily consists of many structurally related proteins that are important structural and functional components of tight junctions in paracellular transport |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CLDN21 |
| Also known as: |
Claudin 22 Polyclonal Antibody |
| Other name: |
Anti-Claudin 22 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Claudin 22 |
| Short name: |
Anti-Claudin 22 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Claudin 22 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2044 |
| Gene: |
CLDN22 |
More about : CLDN22 |
| Long gene name: |
claudin 22 |
| Locus: |
4q35, 1 |
| Discovery year: |
2000-05-19 |
| GenBank acession: |
AK098064 |
| Entrez gene record: |
53842 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000160627 |