| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Claudin 5/CLDN5 |
| Specificity: |
This antibody reacts specifically with Claudin 5/CLDN5 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CLDN5 |
| Gene ID: |
7122 |
| Swiss Prot: |
O00501 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Different tissues exhibit different Claudin composition, They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity, Tight junctions are specialized regions of cell to cell contact, between cells, etc, made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water, Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CPETRL1 BEC1 |
| Also known as: |
Claudin 5/CLDN5 Polyclonal Antibody |
| Other name: |
Anti-Claudin 5/CLDN5 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Claudin 5/CLDN5 |
| Short name: |
Anti-Claudin 5/CLDN5 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Claudin 5/claudin 5 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AWAL and BEC1 and CPETRL1 and TMVCF, CLDN5 and IDBG-1386 and ENSG00000184113 and 7122, CLDN5 and IDBG-647913 and ENSBTAG00000022020 and 617453, Cell surfaces, Cldn5 and IDBG-142207 and ENSMUSG00000041378 and 12741, identical protein binding, this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005923 and tight junction and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016338 and calcium-independent cell-cell adhesion and biological process this GO :0033270 and paranode region of axon and cellular component this GO :0042552 and myelination and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043220 and Schmidt-Lanterman incisure and cellular component this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005198 : structural molecule activity, this GO :0005198 : structural molecule activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, claudin 5 |
| Identity: |
2047 |
| Gene: |
CLDN5 |
More about : CLDN5 |
| Long gene name: |
claudin 5 |
| Synonyms gene: |
AWAL TMVCF |
| Synonyms gene name: |
transmembrane protein deleted in velocardiofacial syndrome |
| Locus: |
22q11, 21 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
AF000959 |
| Entrez gene record: |
7122 |
| Pubmed identfication: |
9441748 9192844 |
| RefSeq identity: |
NM_003277 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000150441 |