| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Claudin 23 |
| Specificity: |
This antibody reacts specifically with Claudin 23 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Claudin 23 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Claudin-23, Expressed in stomach and placenta, Human claudin-23 shares 80% sequence similarity with its mouse counterpart, Overexpression of claudin-23 is associated with colon tumors, also known as CLDN23 or CLDNL, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space, implicating claudin-23 as a possible metastasis factor, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family, suggesting a conserved role between species, The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CLDNL |
| Also known as: |
Claudin 23 Polyclonal Antibody |
| Other name: |
Anti-Claudin 23 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Claudin 23 |
| Short name: |
Anti-Claudin 23 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Claudin 23 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17591 |
| Gene: |
CLDN23 |
More about : CLDN23 |
| Long gene name: |
claudin 23 |
| Locus: |
8p23, 1 |
| Discovery year: |
2004-06-14 |
| GenBank acession: |
AK123547 |
| Entrez gene record: |
137075 |
| Pubmed identfication: |
12736707 |
| RefSeq identity: |
NM_194284 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000163674 |