| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Claudin 2 |
| Specificity: |
This antibody reacts specifically with Claudin 2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Claudin 2 |
| Gene ID: |
9075 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Able to form homopolymers of heteropolymers with other claudin family members, Claudin-2, Overexpression of claudin-2 is associated with a variety of diseases, The gene encoding claudin-2 maps to human chromosome X, also known as CLDN2 or SP82, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space, colorectal cancer, further affirming the importance of claudin-2 in cell adhesion, gastrointestinal carcinomas and inflammatory bowel disease, including lung cancer, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily, which contains nearly 153 million base pairs and houses over 1, 000 genes, The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Claudin 2 Polyclonal Antibody |
| Other name: |
Anti-Claudin 2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Claudin 2 |
| Short name: |
Anti-Claudin 2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Claudin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2041 |
| Gene: |
CLDN2 |
More about : CLDN2 |
| Long gene name: |
claudin 2 |
| Locus: |
Xq22, 3 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
AK075405 |
| Entrez gene record: |
9075 |
| Pubmed identfication: |
9892664 |
| Classification: |
Claudins |
| Havana BLAST/BLAT: |
OTTHUMG00000022154 |
| Locus Specific Databases: |
Mental Retardation database |