| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Integrin beta 1 |
| Specificity: |
This antibody reacts specifically with Integrin beta 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Integrin beta 1 |
| Gene ID: |
3688 |
| Swiss Prot: |
P05556 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration, Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin, Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands, In case of HIV-1 infection, Integrin alpha-1/beta-1, Integrin alpha-3/beta-1 is a receptor for epiligrin, Integrin alpha-4/beta-1 is a receptor for VCAM1, Integrin alpha-5/beta-1 is a receptor for fibrinogen, Integrin alpha-9/beta-1 is a receptor for VCAM1, Integrin alpha-V/beta-1 is a receptor for vitronectin, Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen, Integrins alpha-2/beta-1, Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro), It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin, It recognizes the sequence Q-I-D-S in VCAM1, alpha-10/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin, alpha-2/beta-1, alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin, alpha-8/beta-1, cytotactin and osteopontin, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions, thrombospondin and CSPG4, Integrins alpha-1/beta-1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ITGB1L |
| Also known as: |
Integrin beta 1 Polyclonal Antibody |
| Other name: |
Anti-Integrin beta 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Integrin beta 1 |
| Short name: |
Anti-Integrin beta 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Integrin b 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3781 |
| Gene: |
ITGB1P1 |
More about : ITGB1P1 |
| Long gene name: |
integrin subunit beta 1 pseudogene 1 |
| Synonyms gene: |
FNRBL |
| Synonyms gene name: |
beta polypeptide-like integrin beta 1 pseudogene 1 , fibronectin receptor |
| Locus: |
19p13, 12 |
| Discovery year: |
1989-05-19 |
| Entrez gene record: |
100422691 |
| Pubmed identfication: |
1979054 |
| RefSeq identity: |
NG_024150 |
| Havana BLAST/BLAT: |
OTTHUMG00000183370 |