| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Integrin alpha 2b/CD41 |
| Specificity: |
This antibody reacts specifically with Integrin alpha 2bPolyclonal |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b |
| Gene ID: |
16399 |
| Swiss Prot: |
Q9QUM0 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen, It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain, It recognizes the sequence R-G-D in a wide array of ligands, This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin, Integrin alpha-IIb/beta-3 is a receptor for fibronectin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CD41B CD41 PPP1R93 ITGA2B |
| Also known as: |
Integrin alpha 2bPolyclonal Antibody |
| Other name: |
Anti-Integrin alpha 2bPolyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Integrin alpha 2b |
| Short name: |
Anti-Integrin alpha 2b(Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Integrin a 2b(polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4442 |
| Gene: |
GP2B |
More about : GP2B |
| Long gene name: |
integrin subunit alpha 2b |
| Synonyms gene name: |
alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) , antigen CD41B) integrin, integrin |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 93 platelet glycoprotein IIb of IIb/IIIa complex |
| Locus: |
17q21, 31 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
3674 |
| Classification: |
Integrin alpha subunits CD molecules Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000177935 |
| Locus Specific Databases: |
LRG_479 |