| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Integrin Alpha V + Beta 1 |
| Specificity: |
This antibody reacts specifically with Integrin Alpha V + Beta1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
Mixed KLH conjugated syntheticpeptides for human Integrin Alpha V and human Integrin Beta1 |
| Gene ID: |
3685, 3688 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands, In case of HIV-1 infection, Integrin alpha-V/beta-1 is a receptor for vitronectin, Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro), They recognize the sequence R-G-D in a wide array of ligands, cytotactin, fibrinogen, fibronectin, laminin, matrix metalloproteinase-2, osteomodulin, osteopontin, prothrombin, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions, thrombospondin and vWF, The alpha-V (ITGAV) integrins are receptors for vitronectin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CD29, CD51 Integrin beta-1: Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, VLA-4 subunit beta, Vitronectin receptor subunit alpha, Integrin alpha-V: Integrin alpha-V |
| Also known as: |
Integrin Alpha V + Beta1 Antibody |
| Other name: |
Anti-Integrin Alpha V + Beta1 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
Fluor 594 is a &alpha, - or alpha protein sometimes glycoprotein present in blood, The Anti-Integrin Alpha V + Beta1 |
| Gene target: |
Integrin Alpha V + Beta1 |
| Short name: |
Fluor 594, Anti-Integrin Alpha V + Beta1 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Integrin a V and Beta1 |