Frizzled 4/CD344 Antibody, FITC Conjugated

Catalog number:	bs-13217R-FITC Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Frizzled 4/CD344 Antibody, FITC Conjugated
Quantity:	0.1ml
Related search:	frizzled antibody antibodies conjugated gene receptor proteins fluorescent canonical

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Long name:	FITC Conjugated, Frizzled 4/CD344 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Anti-FITC Antibody
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Frizzled 4/CD344
Specificity:	This is a highly specific antibody against Frizzled 4/CD344
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	190-222/537
Subcellular location:	Extracellular
Source:	KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID number:	8322
Swiss Prot:	Q9ULV1
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	494nm/518nm
Synonyms:	CD344
Properties:	Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Frizzled 4/CD344 Conjugated
Short name:	FITC Conjugated, Frizzled 4/CD344 Antibody
Technique:	Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	FITC
Alternative name:	fluorecein coupled, Frizzled 4/CD344 (Antibody to)
Alternative technique:	antibodies
Identity:	4042
Gene:	FZD4 | More about : FZD4
Long gene name:	frizzled class receptor 4
Synonyms gene:	EVR1
Synonyms gene name:	frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus:	11q14, 2
Discovery year:	1998-09-17
GenBank acession:	AB032417
Entrez gene record:	8322
Pubmed identfication:	10544037 15024691
RefSeq identity:	NM_012193
Classification:	Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT:	OTTHUMG00000167231

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