Frizzled 4/CD344 Antibody, ALEXA FLUOR 350

Catalog number:	bs-13217R-A350 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	Frizzled 4/CD344 Antibody, ALEXA FLUOR 350
Quantity:	100ul
Related search:	frizzled antibody gene antibodies receptor proteins synonyms accumulation

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Long name:	ALEXA FLUOR 350 Conjugated, Frizzled 4/CD344 Polyclonal Antibody
Also known as:	Anti-Frizzled 4/CD344 PAb ALEXA FLUOR 350
Category:	Conjugated Primary Antibodies
Conjugated with:	350, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Frizzled 4/CD344
Specificity:	This is a highly specific antibody against Frizzled 4/CD344
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	190-222/537
Subcellular location:	Extracellular
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID Number:	8322
Swiss Prot:	Q9ULV1
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	343nm/442nm
Synonyms:	CD344
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 350, Alexa Fluor
Gene target:	Frizzled 4/CD344
Short name:	Frizzled 4/CD344 Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 350
Alternative name:	ALEXA FLUOR 350, Frizzled 4/CD344 (Antibody to)
Alternative technique:	antibodies
Identity:	4042
Gene:	FZD4 | More about : FZD4
Long gene name:	frizzled class receptor 4
Synonyms gene:	EVR1
Synonyms gene name:	frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus:	11q14, 2
Discovery year:	1998-09-17
GenBank acession:	AB032417
Entrez gene record:	8322
Pubmed identfication:	10544037 15024691
RefSeq identity:	NM_012193
Classification:	Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT:	OTTHUMG00000167231

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