Frizzled 4/CD344 Antibody, Cy5 Conjugated

Catalog number:	bs-13217R-Cy5 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Frizzled 4/CD344 Antibody, Cy5 Conjugated
Quantity:	0.1ml
Related search:	frizzled antibody gene conjugated receptor proteins synonyms activation

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Long name:	Cy5 Conjugated, Frizzled 4/CD344 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	5, Cy5
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Frizzled 4/CD344
Specificity:	This is a highly specific antibody against Frizzled 4/CD344
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	190-222/537
Subcellular location:	Extracellular
Source:	KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID number:	8322
Swiss Prot:	Q9ULV1
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	625, 650nm/670nm
Synonyms:	CD344
Properties:	Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Frizzled 4/CD344 Conjugated
Short name:	Conjugated, Frizzled 4/CD344 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy5
Alternative name:	cyanine 5 coupled, Frizzled 4/CD344 (Antibody to)
Alternative technique:	antibodies
Identity:	4042
Gene:	FZD4 | More about : FZD4
Long gene name:	frizzled class receptor 4
Synonyms gene:	EVR1
Synonyms gene name:	frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus:	11q14, 2
Discovery year:	1998-09-17
GenBank acession:	AB032417
Entrez gene record:	8322
Pubmed identfication:	10544037 15024691
RefSeq identity:	NM_012193
Classification:	Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT:	OTTHUMG00000167231

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