| Long name: |
ALEXA FLUOR 647 Conjugated, Frizzled 4/CD344 Polyclonal Antibody |
| Also known as: |
Anti-Frizzled 4/CD344 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Frizzled 4/CD344 |
| Specificity: |
This is a highly specific antibody against Frizzled 4/CD344 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
190-222/537 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Frizzled 4/CD344 |
| Gene ID Number: |
8322 |
| Swiss Prot: |
Q9ULV1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
CD344 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Frizzled 4/CD344 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Frizzled 4/CD344 |
| Short name: |
Frizzled 4/CD344 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Frizzled 4/CD344 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4042 |
| Gene: |
FZD4 |
More about : FZD4 |
| Long gene name: |
frizzled class receptor 4 |
| Synonyms gene: |
EVR1 |
| Synonyms gene name: |
frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4 |
| Locus: |
11q14, 2 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AB032417 |
| Entrez gene record: |
8322 |
| Pubmed identfication: |
10544037 15024691 |
| RefSeq identity: |
NM_012193 |
| Classification: |
Class F frizzled CD molecules , G protein-coupled receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000167231 |