Frizzled 4/CD344 Antibody, Biotin Conjugated

Catalog number:	bs-13217R-Biotin Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Frizzled 4/CD344 Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	frizzled antibody gene biotin receptor proteins synonyms accumulation

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Long name:	Biotin Conjugated, Frizzled 4/CD344 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Frizzled 4/CD344
Specificity:	This is a highly specific antibody against Frizzled 4/CD344
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	190-222/537
Subcellular location:	Extracellular
Source:	KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID number:	8322
Swiss Prot:	Q9ULV1
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	CD344
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Frizzled 4/CD344 Conjugated
Short name:	Conjugated, Frizzled 4/CD344 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, Frizzled 4/CD344 (Antibody to)
Alternative technique:	antibodies
Identity:	4042
Gene:	FZD4 | More about : FZD4
Long gene name:	frizzled class receptor 4
Synonyms gene:	EVR1
Synonyms gene name:	frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus:	11q14, 2
Discovery year:	1998-09-17
GenBank acession:	AB032417
Entrez gene record:	8322
Pubmed identfication:	10544037 15024691
RefSeq identity:	NM_012193
Classification:	Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT:	OTTHUMG00000167231

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• #accumulation