| Long name: |
ALEXA FLUOR 488 Conjugated, Frizzled 5/8 Polyclonal Antibody |
| Also known as: |
Anti-Frizzled 5/8 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Frizzled 5/8 |
| Specificity: |
This is a highly specific antibody against Frizzled 5/8 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
27-77/585 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Frizzled 5 |
| Gene ID Number: |
7855, 8325 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes, Coreceptor along with RYK of Wnt proteins, ESTs have been isolated from bone, Frizzled 5 has been reported to be expressed in fetal kidney, Frizzled 5 was cloned from a retina cDNA library, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Receptor for Wnt proteins, The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand, The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, and adult pancreas, and prostate libraries, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, fetal and adult liver, fetal lung, inhibition of GSK-3 kinase, liver/spleen, nuclear accumulation of beta-catenin and activation of Wnt target genes, placenta, such as WNT1, Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
FZD 5, FZD5, FZD5_HUMAN, FZD8, Frizzled homolog 5, Frizzled-5, Frizzled-8, Frizzled5, Fz 5, Fz-5, Fz-8, Fz5, FzE 5, FzE5, HFZ 5, Seven transmembrane receptor frizzled 5, Wnt receptor, hFz5, hFz8, C2orf31 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Frizzled 5/8 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Frizzled 5/8 |
| Short name: |
Frizzled 5/8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Frizzled 5/8 (Antibody to) |
| Alternative technique: |
antibodies |