| Long name: |
ALEXA FLUOR 647 Conjugated, HER2 (Tyr1221) Polyclonal Antibody |
| Also known as: |
Anti-HER2 Tyr1221 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HER2 Tyr1221 |
| Specificity: |
This is a highly specific antibody against HER2 Tyr1221 |
| Modification: |
Phosphorylation |
| Modification Site: |
Tyr1221 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1221 |
| Gene ID Number: |
2064 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, Jul 2008], This protein has no ligand binding domain of its own and therefore cannot bind growth factors, [provided by RefSeq, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HER2 (Tyr1221) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
HER2 (Tyr1221) |
| Short name: |
HER2 (Tyr1221) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, HER2 (Tyr1221) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |