| Long name: |
HER2 (Tyr1221) Primary Polyclonal Antibody |
| Also known as: |
HER2 (Tyr1221) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HER2 Tyr1221 |
| Specificity: |
This is a highly specific antibody against HER2 Tyr1221 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr1221 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1221 |
| Gene ID number: |
2064 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, Jul 2008], This protein has no ligand binding domain of its own and therefore cannot bind growth factors, [provided by RefSeq, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C erbB 2, C-erbB2, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, ERBB2_HUMAN, Erb B2, ErbB2, HER 2, HER 2/neu, HER2, HER2Tyr1221, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU Proto Oncogene, NGL, Neuro Glioblastoma Derived Oncogene Homolog, Neuroblastoma/glioblastoma derived oncogene homolog, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, c erb B2, erbb2, p-ErbB 2 phospho Y1221, p185 ErbB2, p185erbB2, ErbB 2 phospho Y1221 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HER2 (Tyr1221) |
| Short name: |
HER2 (Tyr1221) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HER2 (Tyr1221) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |