ATF1 (Ser63) Antibody

Catalog number:	bs-12535R Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	ATF1 (Ser63) Antibody
Quantity:	0.1ml
Related search:	atf transcription factor antibodies treb activating dependent bzip

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Long name:	ATF1 (Ser63) Primary Polyclonal Antibody
Also known as:	ATF1 (Ser63) PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	ATF1 Ser63
Specificity:	This is a highly specific antibody against ATF1 Ser63
Modification(s):	Phosphorylation
Modification site(s):	Ser63
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from human ATF1 around the phosphorylation site of Ser63
Gene ID number:	466
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	A chimeric protein composed of the N-terminal domain of EWS (Ewing sarcoma oncogene) linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath and aponeuroses (malignant melanoma of soft parts), ATF1 is a nuclear protein that binds DNA as a homodimer or as heterodimers with the inducible transcription factors CREB1 or CREM, ATF1 is detectable in metastatic melanoma cells and seems to contribute to their survival, ATF1 mediates both Ca2+ and cAMP responses at several levels, Heterodimers appear to be stronger transcriptional activators than the homodimers, It binds to the Tax-responsive element (TRE1) of the human T-cell lymphotropic virus type-I (HTLV1), Many of these genes are important in cell growth and differentiation, Several isoforms of ATF1 arise by differential splicing, TREB-36) is a member of the ATF/CREB family of basic region leucine-zipper (bZip) DNA-binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes, The activation function of CRE-binding proteins may be modulated by phosphorylation of several kinases and is mediated by coactivators such as CREB-binding protein (CBP) and p300, Tissue expression of ATF1 mRNA is widespread, and in stress and immune responses, ATF1 (Activating Transcription Factor 1
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	ATF 1, ATF1 EWS fusion gene ATF1 FUS fusion gene, Activating Transcription Factor1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1, EWS AFT1, FUS ATF 1, RNA binding protein activating transcription factor 1 fusion protein, TREB 36, TREB36, TREB36 protein, cAMP dependent transcription factor 1, p-ATF1 phospho S63, ATF1 phospho S63
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	ATF1 (Ser63)
Short name:	ATF1 (Ser63) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	ATF1 (Ser63) (Antibody to)
Alternative technique:	antibodies
Identity:	783
Gene:	ATF1 | More about : ATF1
Long gene name:	activating transcription factor 1
Synonyms:	TREB36
Locus:	12q13, 12
Discovery year:	1994-03-16
GenBank acession:	BC029619
Entrez gene record:	466
Pubmed identfication:	8401579
RefSeq identity:	NM_005171
Classification:	Basic leucine zipper proteins
Havana BLAST/BLAT:	OTTHUMG00000169482

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