| Long name: |
CSEN (Ser63) Primary Polyclonal Antibody |
| Also known as: |
CSEN (Ser63) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CSEN Ser63 |
| Specificity: |
This is a highly specific antibody against CSEN Ser63 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser63 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Membrane bound |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CSEN around the phosphorylation site of Ser63 |
| Gene ID number: |
30818 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DRE is a regulatory sequence that silences basal transcription and is localized to the promoter region of the gene encoding human prodynorphin, DREAM forms functional homotetramers that are required for the interaction with the DRE, DREAM has been shown to inhibit transcription of other proteins containing DRE-like motifs, DREAM transcripts are detected in brain, This association is highly influenced by calcium, an opioid peptide involved in memory acquisition and pain, and it is expressed as a nuclear protein, as an increase in Ca2+ directly inhibits DREAM binding and thereby blocks the repressor activity of DREAM, including the gene encoding for the AP-1 transcription factor c-Fos, suggesting that DREAM may influence a wide variety of cellular genes, thymus and thyroid gland, CSEN is a Ca2+-regulated transcriptional repressor that specifically binds to the downstream regulatory elements (DRE) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
A-type potassium channel modulatory protein 3, CSEN, DRE-antagonist modulator, DREAM, KCHIP3, KCNIP3, KChIP3, Kv channel-interacting protein 3, Calsenilin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CSEN (Ser63) |
| Short name: |
CSEN (Ser63) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CSEN (Ser63) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
15523 |
| Gene: |
KCNIP3 |
More about : KCNIP3 |
| Long gene name: |
potassium voltage-gated channel interacting protein 3 |
| Synonyms gene: |
CSEN |
| Synonyms gene name: |
EF hand transcription factor Kv channel interacting protein 3, calsenilin, calsenilin , presenilin-binding protein |
| Synonyms: |
DREAM KCHIP3 |
| Synonyms name: |
calsenilin |
| Locus: |
2q11, 1 |
| Discovery year: |
2001-05-24 |
| GenBank acession: |
AF199599 |
| Entrez gene record: |
30818 |
| Pubmed identfication: |
9771752 10078534 |
| RefSeq identity: |
NM_013434 |
| Classification: |
Potassium voltage-gated channel regulatory subunits EF-hand domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130392 |