Senataxin/SETX Antibody, Cy5.5 Conjugated

Catalog number:	bs-11693R-Cy5.5 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Senataxin/SETX Antibody, Cy5.5 Conjugated
Quantity:	0.1ml
Related search:	pubmed antibody gene rna senataxinsetx transcription database termination

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Long name:	Cy5, 5 Conjugated, Senataxin/SETX Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy5, 5, 5, Cy5
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Senataxin/SETX
Specificity:	This is a highly specific antibody against Senataxin/SETX
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	345-395/2677
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic peptide derived from human Senataxin
Gene ID number:	23064
Swiss Prot:	Q7Z333
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	675nm/694nm
Synonyms:	KIAA0625 AOA2
Properties:	Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene target:	Senataxin/SETX Conjugated
Short name:	Conjugated, Senataxin/SETX Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	5, Cy5
Alternative name:	cyanine 5, 5 coupled, Senataxin/SETX (Antibody to)
Alternative technique:	antibodies
Identity:	445
Gene:	SETX | More about : SETX
Long gene name:	senataxin
Synonyms gene:	ALS4 SCAR1
Synonyms gene name:	amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive
Locus:	9q34, 13
Discovery year:	1996-10-26
GenBank acession:	AB014525
Entrez gene record:	23064
Pubmed identfication:	9497266 11022012
RefSeq identity:	NM_015046
Classification:	UPF1 like RNA helicases
Havana BLAST/BLAT:	OTTHUMG00000020834
Locus Specific Databases:	Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268

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