| Long name: |
Senataxin/SETX Primary Polyclonal Antibody |
| Also known as: |
Senataxin/SETX PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Senataxin/SETX |
| Specificity: |
This is a highly specific antibody against Senataxin/SETX |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
345-395/2677 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Senataxin |
| Gene ID number: |
23064 |
| Swiss Prot: |
Q7Z333 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AOA2, Amyotrophic lateral sclerosis 4 protein, KIAA0625, Probable helicase senataxin, SCAR1, SEN1 homolog, SETX, Senataxin, bA479K20, 2, ALS4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Senataxin/SETX |
| Short name: |
Senataxin/SETX Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Senataxin/SETX (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
445 |
| Gene: |
SETX |
More about : SETX |
| Long gene name: |
senataxin |
| Synonyms gene: |
ALS4 SCAR1 |
| Synonyms gene name: |
amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive |
| Synonyms: |
KIAA0625 AOA2 |
| Locus: |
9q34, 13 |
| Discovery year: |
1996-10-26 |
| GenBank acession: |
AB014525 |
| Entrez gene record: |
23064 |
| Pubmed identfication: |
9497266 11022012 |
| RefSeq identity: |
NM_015046 |
| Classification: |
UPF1 like RNA helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000020834 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268 |