| Long name: |
ALEXA FLUOR 555 Conjugated, Senataxin/SETX Polyclonal Antibody |
| Also known as: |
Anti-Senataxin/SETX PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Senataxin/SETX |
| Specificity: |
This is a highly specific antibody against Senataxin/SETX |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
345-395/2677 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Senataxin |
| Gene ID Number: |
23064 |
| Swiss Prot: |
Q7Z333 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
KIAA0625 AOA2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
Senataxin/SETX |
| Short name: |
Senataxin/SETX Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, Senataxin/SETX (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
445 |
| Gene: |
SETX |
More about : SETX |
| Long gene name: |
senataxin |
| Synonyms gene: |
ALS4 SCAR1 |
| Synonyms gene name: |
amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive |
| Locus: |
9q34, 13 |
| Discovery year: |
1996-10-26 |
| GenBank acession: |
AB014525 |
| Entrez gene record: |
23064 |
| Pubmed identfication: |
9497266 11022012 |
| RefSeq identity: |
NM_015046 |
| Classification: |
UPF1 like RNA helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000020834 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268 |