| Long name: |
FITC Conjugated, Senataxin/SETX Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Senataxin/SETX |
| Specificity: |
This is a highly specific antibody against Senataxin/SETX |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
345-395/2677 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Senataxin |
| Gene ID number: |
23064 |
| Swiss Prot: |
Q7Z333 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850), In association with RRP45, Inhibits retinoic acid-induced apoptosis (PubMed:21576111), Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789), May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256), Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways, Plays a role in the development and maturation of germ cells: essential for male meiosis, Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224), PubMed:21700224), Required for the 3' transcriptional termination of PER1 and CRY2, Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, acting at the interface of transcription and meiotic recombination, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity), targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744), thus playing an important role in the circadian rhythm regulation (By similarity), Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA0625 AOA2 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Senataxin/SETX Conjugated |
| Short name: |
FITC Conjugated, Senataxin/SETX Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Senataxin/SETX (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
445 |
| Gene: |
SETX |
More about : SETX |
| Long gene name: |
senataxin |
| Synonyms gene: |
ALS4 SCAR1 |
| Synonyms gene name: |
amyotrophic lateral sclerosis 4 spinocerebellar ataxia, non-Friedreich type 1 , recessive |
| Locus: |
9q34, 13 |
| Discovery year: |
1996-10-26 |
| GenBank acession: |
AB014525 |
| Entrez gene record: |
23064 |
| Pubmed identfication: |
9497266 11022012 |
| RefSeq identity: |
NM_015046 |
| Classification: |
UPF1 like RNA helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000020834 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LOVD - Leiden Open Variation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_268 |