| Long name: |
Biotin Conjugated, FE65 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FE65 |
| Specificity: |
This is a highly specific antibody against FE65 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
225-265/710 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Fe65 protein |
| Gene ID number: |
322 |
| Swiss Prot: |
O00213 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain, Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s), Function in association with TSHZ3, Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis, Required for histone H4 acetylation at double-strand breaks (DSBs), SET and HDAC factors as a transcriptional repressor, probably explains its trancription activation activity, recruiting other pro-apoptosis factors such as MAPK8/JNK1, that inhibits the expression of CASP4, Transcription coregulator that can have both coactivator and corepressor functions |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Fe65 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FE65 Conjugated |
| Short name: |
Conjugated, FE65 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, FE65 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
581 |
| Gene: |
APBB1 |
More about : APBB1 |
| Long gene name: |
amyloid beta precursor protein binding family B member 1 |
| Synonyms gene: |
RIR |
| Synonyms gene name: |
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| Locus: |
11p15, 4 |
| Discovery year: |
1997-03-27 |
| GenBank acession: |
L77864 |
| Entrez gene record: |
322 |
| Pubmed identfication: |
8955346 8894693 |
| RefSeq identity: |
NM_001164 |
| Havana BLAST/BLAT: |
OTTHUMG00000165454 |