FHIT (Tyr114) Antibody, Biotin Conjugated

Catalog number:	bs-3146R-Biotin Buy Now
Price:	311 €
Supplier:	acr
Product name:	FHIT (Tyr114) Antibody, Biotin Conjugated
Quantity:	0,1 ml
Related search:	fhit antibody tyr gene biotin apoptosis conjugates

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Long name:	Biotin Conjugated, FHIT (Tyr114) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	FHIT Tyr114
Specificity:	This is a highly specific antibody against FHIT Tyr114
Modification:	Phosphorylation
Modification site:	Tyr114
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	90-130/147
Subcellular location:	Mitochondrion, Nucleus, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human FHIT around the phosphorylation site of Tyr114
Gene ID number:	2272
Swiss Prot:	P49789
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	FRA3B AP3Aase
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	FHIT (Tyr114) Conjugated
Short name:	Conjugated, FHIT (Tyr114) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, FHIT (Tyr114) (Antibody to)
Alternative technique:	antibodies
Identity:	3701
Gene:	FHIT | More about : FHIT
Long gene name:	fragile histidine triad
Synonyms gene name:	fragile histidine triad gene
Locus:	3p14, 2
Discovery year:	1996-10-18
GenBank acession:	BC032336
Entrez gene record:	2272
Pubmed identfication:	8598045 9671749 26181368
RefSeq identity:	NM_002012
Havana BLAST/BLAT:	OTTHUMG00000158591

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• #biotin
• #apoptosis
• #conjugates