| Long name: |
FHIT (Tyr114) Primary Polyclonal Antibody |
| Also known as: |
FHIT (Tyr114) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FHIT Tyr114 |
| Specificity: |
This is a highly specific antibody against FHIT Tyr114 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr114 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
90-130/147 |
| Subcellular location: |
Mitochondrion, Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human FHIT around the phosphorylation site of Tyr114 |
| Gene ID number: |
2272 |
| Swiss Prot: |
P49789 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AP3A hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5', Dinucleosidetriphosphatase, FHIT, Fragile histidine triad protein, 5'''-P1, FRA3B, P3-triphosphate hydrolase |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FHIT (Tyr114) |
| Short name: |
FHIT (Tyr114) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FHIT (Tyr114) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3701 |
| Gene: |
FHIT |
More about : FHIT |
| Long gene name: |
fragile histidine triad |
| Synonyms gene name: |
fragile histidine triad gene |
| Synonyms: |
FRA3B AP3Aase |
| Locus: |
3p14, 2 |
| Discovery year: |
1996-10-18 |
| GenBank acession: |
BC032336 |
| Entrez gene record: |
2272 |
| Pubmed identfication: |
8598045 9671749 26181368 |
| RefSeq identity: |
NM_002012 |
| Havana BLAST/BLAT: |
OTTHUMG00000158591 |