| Long name: |
Cy5, 5 Conjugated, FHIT Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FHIT |
| Specificity: |
This is a highly specific antibody against FHIT |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
47-72/147 |
| Subcellular location: |
Mitochondrion, Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human FHIT |
| Gene ID number: |
2272 |
| Swiss Prot: |
P49789 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
FRA3B AP3Aase |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
FHIT Conjugated |
| Short name: |
Conjugated, FHIT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, FHIT (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3701 |
| Gene: |
FHIT |
More about : FHIT |
| Long gene name: |
fragile histidine triad |
| Synonyms gene name: |
fragile histidine triad gene |
| Locus: |
3p14, 2 |
| Discovery year: |
1996-10-18 |
| GenBank acession: |
BC032336 |
| Entrez gene record: |
2272 |
| Pubmed identfication: |
8598045 9671749 26181368 |
| RefSeq identity: |
NM_002012 |
| Havana BLAST/BLAT: |
OTTHUMG00000158591 |