| Long name: |
ALEXA FLUOR 647 Conjugated, Spinophilin/Neurabin 2 Antibody |
| Also known as: |
Anti-Spinophilin/Neurabin 2 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Spinophilin/Neurabin 2 |
| Specificity: |
This is a highly specific antibody against Spinophilin/Neurabin 2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
360-410/815 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Spinophilin/Neurabin 2 |
| Gene ID Number: |
84687 |
| Swiss Prot: |
Q96SB3 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Believed to target protein phosphatase 1/PP1 to dendritic spines, Binds along the sides of the F-actin, Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling, Binds to actin filaments (F-actin) and shows cross-linking activity, May confer to Rac signaling specificity by binding to both, May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton, May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction, Modulates excitatory synaptic transmission and dendritic spine morphology, Plays a role in regulation of G-protein coupled receptor signaling, Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity), RacGEFs and Rac effector proteins, Required for hepatocyte growth factor (HGF)-induced cell migration, and regulates its specificity toward ion channels and other substrates, including dopamine D2 receptors and alpha-adrenergic receptors, such as AMPA-type and NMDA-type glutamate receptors, which are rich in F-actin, Seems to act as a scaffold protein in multiple signaling pathways |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
Neurabin-2, Neurabin-II, PPP1R6, PPP1R9, PPP1R9B, Protein phosphatase 1 regulatory subunit 9B, SPINO, Spinophilin, Spn |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Spinophilin/Neurabin 2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Spinophilin/Neurabin 2 |
| Short name: |
Spinophilin/Neurabin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Spinophilin/Neurabin 2 (Antibody to) |
| Alternative technique: |
antibodies |