| Long name: |
Biotin Conjugated, Neurabin 1/PPP1R9A Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Neurabin 1/PPP1R9A |
| Specificity: |
This is a highly specific antibody against Neurabin 1/PPP1R9A |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Neurabin 1 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Neurabin I recruits active PP1 via a PP1-docking sequence, Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4), Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4), Neurabin II localizes to neuronal dentritic spines, Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5), Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5), Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1), it localizes in the growth cone lamellipodia during neuronal development (1), mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5), 3), Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Neurabin-I KIAA1222 FLJ20068 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Neurabin 1/PPP1R9A Conjugated |
| Short name: |
Conjugated, Neurabin 1/PPP1R9A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Neurabin 1/PPP1R9A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14946 |
| Gene: |
PPP1R9A |
More about : PPP1R9A |
| Long gene name: |
protein phosphatase 1 regulatory subunit 9A |
| Synonyms gene name: |
protein phosphatase 1, regulatory (inhibitor) subunit 9A protein phosphatase 1, regulatory subunit 9A |
| Locus: |
7q21, 3 |
| Discovery year: |
2001-06-29 |
| GenBank acession: |
AB033048 |
| Entrez gene record: |
55607 |
| Pubmed identfication: |
10574462 |
| RefSeq identity: |
NM_001166160 |
| Classification: |
Sterile alpha motif domain containing Protein phosphatase 1 regulatory subunits PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000155566 |