| Long name: |
Neurabin 1/PPP1R9A Primary Polyclonal Antibody |
| Also known as: |
Neurabin 1/PPP1R9A PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Neurabin 1/PPP1R9A |
| Specificity: |
This is a highly specific antibody against Neurabin 1/PPP1R9A |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Neurabin 1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Neurabin I recruits active PP1 via a PP1-docking sequence, Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4), Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4), Neurabin II localizes to neuronal dentritic spines, Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5), Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5), Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1), it localizes in the growth cone lamellipodia during neuronal development (1), mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5), 3), Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
KIAA1222, NEB1_HUMAN, NRB 1, NRB I, NRB1, NRBI, Neurabin I, Neurabin-1, Neurabin-1, Neurabin-I, Neurabin1, Neurabin1, NeurabinI, Neural tissue specic F actin binding protein I, Neural tissue-specic F-actin-binding protein I, PPP1R9A, Protein phosphatase 1 regulatory inhibitor subunit 9A, Protein phosphatase 1 regulatory subunit 9A, FLJ20068 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Neurabin 1/PPP1R9A |
| Short name: |
Neurabin 1/PPP1R9A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Neurabin 1/PPP1R9A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14946 |
| Gene: |
PPP1R9A |
More about : PPP1R9A |
| Long gene name: |
protein phosphatase 1 regulatory subunit 9A |
| Synonyms gene name: |
protein phosphatase 1, regulatory (inhibitor) subunit 9A protein phosphatase 1, regulatory subunit 9A |
| Synonyms: |
Neurabin-I KIAA1222 FLJ20068 |
| Locus: |
7q21, 3 |
| Discovery year: |
2001-06-29 |
| GenBank acession: |
AB033048 |
| Entrez gene record: |
55607 |
| Pubmed identfication: |
10574462 |
| RefSeq identity: |
NM_001166160 |
| Classification: |
Sterile alpha motif domain containing Protein phosphatase 1 regulatory subunits PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000155566 |