| Long name: |
Biotin Conjugated, Exportin 1/CRM1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Exportin 1/CRM1 |
| Specificity: |
This is a highly specific antibody against Exportin 1/CRM1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
720-770/1071 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Exportin 1/CRM1 |
| Gene ID number: |
7514 |
| Swiss Prot: |
O14980 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to late precursor U3 snoRNA bearing a TMG cap, Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus, In the nucleus, Interacts with, Involved in HTLV-1 Rex multimerization, Involved in U3 snoRNA transport from Cajal bodies to nucleoli, Several viruses, The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, Upon transit of a nuclear export complex into the cytoplasm, among them HIV-1, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP), disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, in association with RANBP3, respectively) cause release of the cargo from the export receptor, Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
CRM1 emb |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Exportin 1/CRM1 Conjugated |
| Short name: |
Conjugated, Exportin 1/CRM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Exportin 1/CRM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12825 |
| Gene: |
XPO1 |
More about : XPO1 |
| Long gene name: |
exportin 1 |
| Synonyms gene name: |
exportin 1 (CRM1, homolog) exportin 1 (CRM1 homolog, yeast, yeast) |
| Synonyms name: |
chromosome region maintenance 1 homolog (yeast) |
| Locus: |
2p15 |
| Discovery year: |
1998-05-12 |
| GenBank acession: |
Y08614 |
| Entrez gene record: |
7514 |
| Pubmed identfication: |
9205132 9368044 |
| RefSeq identity: |
NM_003400 |
| Classification: |
Exportins |
| Havana BLAST/BLAT: |
OTTHUMG00000152316 |