| Long name: |
FITC Conjugated, Exportin 1/CRM1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Exportin 1/CRM1 |
| Specificity: |
This is a highly specific antibody against Exportin 1/CRM1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
720-770/1071 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Exportin 1/CRM1 |
| Gene ID number: |
7514 |
| Swiss Prot: |
O14980 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to late precursor U3 snoRNA bearing a TMG cap, Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus, In the nucleus, Interacts with, Involved in HTLV-1 Rex multimerization, Involved in U3 snoRNA transport from Cajal bodies to nucleoli, Several viruses, The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, Upon transit of a nuclear export complex into the cytoplasm, among them HIV-1, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP), disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, in association with RANBP3, respectively) cause release of the cargo from the export receptor, Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
CRM1 emb |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Exportin 1/CRM1 Conjugated |
| Short name: |
FITC Conjugated, Exportin 1/CRM1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Exportin 1/CRM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12825 |
| Gene: |
XPO1 |
More about : XPO1 |
| Long gene name: |
exportin 1 |
| Synonyms gene name: |
exportin 1 (CRM1, homolog) exportin 1 (CRM1 homolog, yeast, yeast) |
| Synonyms name: |
chromosome region maintenance 1 homolog (yeast) |
| Locus: |
2p15 |
| Discovery year: |
1998-05-12 |
| GenBank acession: |
Y08614 |
| Entrez gene record: |
7514 |
| Pubmed identfication: |
9205132 9368044 |
| RefSeq identity: |
NM_003400 |
| Classification: |
Exportins |
| Havana BLAST/BLAT: |
OTTHUMG00000152316 |