Estrogen Receptor alpha Antibody, ALEXA FLUOR 594

Catalog number:	bs-0122R-A594 Buy Now
Price:	489 €
Supplier:	Bioss Polyclonal Antibodies
Product name:	Estrogen Receptor alpha Antibody, ALEXA FLUOR 594
Quantity:	100 microliters
Other quantities:	100ul 332€
Related search:	receptor alexa alpha gene antibodies nfkappab nuclear displace

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Long name:	ALEXA FLUOR 594 Conjugated, Estrogen Receptor alpha Antibody
Also known as:	Anti-Estrogen Receptor alpha PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Estrogen Receptor alpha
Specificity:	This is a highly specific antibody against Estrogen Receptor alpha
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	310-360/600
Subcellular location:	Intracellular
Source:	KLH conjugated synthetic peptide derived from rat Estrogen Receptor alpha
Gene ID Number:	24890
Swiss Prot:	P06211
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	ATF-2, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Can activate the transcriptional activity of TFF1, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity), Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Sp1 and Sp3, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, c-Fos, such as AP-1/c-Jun, the function involves CREBBP, to mediate ERE-independent signaling, Nuclear hormone receptor
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	ERR1 ERRalpha NR3B1 ERRa
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	Estrogen Receptor alpha
Short name:	Estrogen Receptor alpha Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, Estrogen Receptor a (Antibody to)
Alternative technique:	antibodies
Identity:	3471
Gene:	ESRRA | More about : ESRRA
Long gene name:	estrogen related receptor alpha
Synonyms gene:	ESRL1
Locus:	11q13, 1
Discovery year:	1997-04-25
GenBank acession:	X51416 L38487
Entrez gene record:	2101
Pubmed identfication:	3267207
RefSeq identity:	NM_004451
Classification:	Nuclear hormone receptors
Havana BLAST/BLAT:	OTTHUMG00000150641

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