| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Estrogen Related Receptor gamma |
| Specificity: |
This antibody reacts specifically with Estrogen Related Receptor gamma |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ESRRG/Estrogen Related Receptor gamma |
| Gene ID: |
2104 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All members of the ESRR family share an almost identical DNA binding domain, It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, Multiple alternatively spliced transcript variants have been identified, The ESRR family is closely related to the estrogen receptor (ER) family, The ESRR members are orphan nuclear receptors, They share target genes, and activate genes controlled by both response elements in the absence of any ligands, and by targeting the same set of genes, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation, co-regulators and promoters, modulates cell proliferation and estrogen signaling in breast cancer, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways, they bind to the estrogen response element and steroidogenic factor 1 response element, which belongs to the nuclear hormone receptor superfamily, which is composed of two C4-type zinc finger motifs, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region, This gene encodes a member of the estrogen receptor-related receptor (ESRR) family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ERR G2, ERR gamma 2, ERR gamma-2, ERR3, ERR3_HUMAN, ERRG 2, ERRG2, ESRRG, Estrogen receptor related protein 3, Estrogen receptor-related protein 3, Estrogen-related receptor gamma, NR3B3, Nuclear receptor subfamily 3 group B member 3, ERR 3 |
| Also known as: |
Estrogen Related Receptor gamma Antibody |
| Other name: |
Anti-Estrogen Related Receptor gamma |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Estrogen Related Receptor gamma |
| Short name: |
Fluor 594, Anti-Estrogen Receptor gamma |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Estrogen Related Receptor g |