Anti-Estrogen Receptor alpha, ALEXA Fluor 594

Catalog number:	GENTAUR-58be59d34c412 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	Anti-Estrogen Receptor alpha, ALEXA Fluor 594
Quantity:	100ul
Other quantities:	100 microliters 489€
Related search:	receptor estrogen alpha nfkappab species fluor displace

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Type:	Conjugated Primary Antibody
Conjugated with:	594, ALEXA FLUOR®
Host organism:	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide:	Estrogen Receptor alpha
Specificity:	This antibody reacts specifically with Estrogen Receptor alpha
Modification:	No modification has been applied to this antibody
Modification site:	None
Clonality:	Polyclonal Antibody
Clone:	Polyclonal Antibodies
Concentration:	1ug per 1ul
Subcellular locations:	Nucleus, Cytoplasm
Antigen Source:	KLH conjugated synthetic peptide derived from rat ER-alpha
Gene ID:	24890
Swiss Prot:	P06211
Applications:	IF(IHC-P)
Applications with corresponding dilutions:	IF(IHC-P)(1:50-200)
Cross reactive species:	Rat (Rattus norvegicus), Mouse (Mus musculus)
Cross Reactive Species details:	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information:	ATF-2, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Can activate the transcriptional activity of TFF1, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity), Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Sp1 and Sp3, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, c-Fos, such as AP-1/c-Jun, the function involves CREBBP, to mediate ERE-independent signaling, Nuclear hormone receptor
Purification method:	Purified by Protein A
Storage:	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission:	590nm/617nm
Synonyms:	ER, ER-alpha, Esr1, Estr, Estradiol receptor, Estrogen receptor, Nr3a1, Nuclear receptor subfamily 3 group A member 1, RNESTROR, Esr
Also known as:	Estrogen Receptor alpha Antibody
Other name:	Anti-Estrogen Receptor alpha
Advisory:	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties:	For facs or microscopy Alexa 1 conjugate
Conjugation:	Alexa Fluor
Gene target:	Estrogen Receptor alpha
Short name:	Fluor 594, Anti-Estrogen Receptor alpha
Label:	ALEXA
Alternative name:	ALEXA Fluor 594, antibody to-Estrogen Receptor a

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