| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TBK1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the TBK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TBK1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UHD2 |
| Purity: |
Antigen affinity |
| Description: |
Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors, The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK, thereby allowing activation and nuclear translocation of the NFKB complex, which inactivate NFKB by trapping it in the cytoplasm, The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins |
| Immunogen: |
A portion of amino acids 150-181 from the human protein was used as the immunogen for this TBK1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TBK1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TBK1 |
| Short name: |
TBK1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TANK-binding kinase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, TBK1 and IDBG-44993 and ENSG00000183735 and 29110, TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141, Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480, this GO :0002218 and activation of innate immune response and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0009615 and response to virus and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, this GO :0003676 : nucleic acid binding, this GO :0003676 : nucleic acid binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0051219 : phosphoprotein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0051219 : phosphoprotein binding, transferring phosphorus-containing groups and molecular function this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032606 and type I interferon production and biological process this GO :0032727 and positive regulation of interferon-alpha production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0044565 and dendritic cell proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051607 and defense response to virus and biological process, TANK-binding kinase 1 |
| Identity: |
11584 |
| Gene: |
TBK1 |
More about : TBK1 |
| Long gene name: |
TANK binding kinase 1 |
| Synonyms gene name: |
TANK-binding kinase 1 |
| Synonyms: |
NAK |
| Locus: |
12q14, 2 |
| Discovery year: |
2000-06-08 |
| GenBank acession: |
AF191838 |
| Entrez gene record: |
29110 |
| Pubmed identfication: |
10581243 10783893 |
| RefSeq identity: |
NM_013254 |
| Havana BLAST/BLAT: |
OTTHUMG00000168796 |