| Long name: |
TBK1 (Ser172) Primary Polyclonal Antibody |
| Also known as: |
TBK1 (Ser172) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TBK1 Ser172 |
| Specificity: |
This phosphorylation site is homologous across the listed species, This is a highly specific antibody against TBK1 Ser172 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser172 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
150-200/729 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172 |
| Gene ID number: |
29110 |
| Swiss Prot: |
Q9UHD2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AZI2, Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C, Following activation of toll-like receptors by viral or bacterial components, IKBKB or RELA to translocate NF-Kappa-B to the nucleus, In order to establish such an antiviral state, MAVS, Phosphorylates Borna disease virus (BDV) P protein, Phosphorylates and activates AKT1, Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', Seems to play a role in energy balance regulation by sustaining a state of chronic, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli, TRADD, This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB, Thus, Under particular conditions, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, low-grade inflammation in obesity, several scaffolding molecules including FADD, thus enhancing LC3 binding affinity and antibacterial autophagy, wich leads to a negative impact on insulin sensitivity, Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NF-kappa-B-activating kinase, Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1, TBK1, NAK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TBK1 (Ser172) |
| Short name: |
TBK1 (Ser172) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TANK-binding kinase 1 (Ser172) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, TBK1 and IDBG-44993 and ENSG00000183735 and 29110, TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141, Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480, this GO :0002218 and activation of innate immune response and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0009615 and response to virus and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, this GO :0003676 : nucleic acid binding, this GO :0003676 : nucleic acid binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0051219 : phosphoprotein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0051219 : phosphoprotein binding, transferring phosphorus-containing groups and molecular function this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032606 and type I interferon production and biological process this GO :0032727 and positive regulation of interferon-alpha production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0044565 and dendritic cell proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051607 and defense response to virus and biological process, TANK-binding kinase 1 |
| Identity: |
11584 |
| Gene: |
TBK1 |
More about : TBK1 |
| Long gene name: |
TANK binding kinase 1 |
| Synonyms gene name: |
TANK-binding kinase 1 |
| Synonyms: |
NAK |
| Locus: |
12q14, 2 |
| Discovery year: |
2000-06-08 |
| GenBank acession: |
AF191838 |
| Entrez gene record: |
29110 |
| Pubmed identfication: |
10581243 10783893 |
| RefSeq identity: |
NM_013254 |
| Havana BLAST/BLAT: |
OTTHUMG00000168796 |