| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TBK1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TBK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TBK1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UHD2 |
| Purity: |
Antigen affinity |
| Description: |
Serine/threonine kinases plays an essential role in regulating inflammatory responses to foreign agents, TBK1 and NF-kappa-B signaling are essential in KRAS mutant tumors, The gene was assigned to human chromosome 12q14, and established a general approach for the rational identification of codependent pathways in cancer, 2, Serine/threonine-protein kinase TANK-binding kinase 1 or NF-kappa-B-activating kinase is an enzyme that in humans is encoded by the TBK1 gene |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human TANK-binding kinase 1 (YNEEQIHKFDKQKL) was used as the immunogen for this TBK1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TBK1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TBK1 |
| Short name: |
TBK1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TANK-binding kinase 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, TBK1 and IDBG-44993 and ENSG00000183735 and 29110, TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141, Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480, this GO :0002218 and activation of innate immune response and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003676 and nucleic acid binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0009615 and response to virus and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, this GO :0003676 : nucleic acid binding, this GO :0003676 : nucleic acid binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0051219 : phosphoprotein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0051219 : phosphoprotein binding, transferring phosphorus-containing groups and molecular function this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032606 and type I interferon production and biological process this GO :0032727 and positive regulation of interferon-alpha production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0044565 and dendritic cell proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051607 and defense response to virus and biological process, TANK-binding kinase 1 |
| Identity: |
11584 |
| Gene: |
TBK1 |
More about : TBK1 |
| Long gene name: |
TANK binding kinase 1 |
| Synonyms gene name: |
TANK-binding kinase 1 |
| Synonyms: |
NAK |
| Locus: |
12q14, 2 |
| Discovery year: |
2000-06-08 |
| GenBank acession: |
AF191838 |
| Entrez gene record: |
29110 |
| Pubmed identfication: |
10581243 10783893 |
| RefSeq identity: |
NM_013254 |
| Havana BLAST/BLAT: |
OTTHUMG00000168796 |