| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Hamartin (TSC1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IF, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the Hamartin antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Hamartin antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92574 |
| Purity: |
Antigen affinity |
| Description: |
Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes, Cortical dysplasias display a broad spectrum of structural changes, Defects in TSC1 are the cause of tuberous sclerosis complex (TSC), Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC), FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy, Interaction between TSC1 and TSC2 may facilitate vesicular docking, May have a function in vesicular transport, TSC is an autosomal dominant multi-system disorder that affects especially the brain, TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination), The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex, and apoptosis of neuronal precursors and neurons during cortical development, and skin, differentiation, heart, kidneys, migration, which appear to result from changes in proliferation, Implicated as a tumor suppressor |
| Immunogen: |
A portion of amino acids 401-430 from the human protein was used as the immunogen for this Hamartin antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Hamartin antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Hamartin (TSC1) |
| Short name: |
Hamartin Antibody (TSC1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Hamartin (Antibody to) (TSC1) |
| Alternative technique: |
antibodies |
| Identity: |
12362 |
| Gene: |
TSC1 |
More about : TSC1 |
| Long gene name: |
tuberous sclerosis 1 |
| Synonyms gene: |
TSC |
| Synonyms: |
KIAA0243 LAM hamartin |
| Locus: |
9q34 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF013168 |
| Pubmed identfication: |
9242607 10806479 |
| Havana BLAST/BLAT: |
OTTHUMG00000020844 |
| Locus Specific Databases: |
TSC Mutation Database Tuberous sclerosis database LRG_486 |