| Long name: |
FITC Conjugated, Hamartin/TSC1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Hamartin/TSC1 |
| Specificity: |
This is a highly specific antibody against Hamartin/TSC1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Hamartin |
| Gene ID number: |
7248 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, TSC1 interacts with tuberin m(TSC2), The Hamartin/Tuberin complex has been shown to inhibit mTor, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1, or TSC1, suggesting a role for TSC proteins in modulation of cell adhesion and morphology, which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins, Hamartin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA0243 LAM hamartin |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Hamartin/TSC1 Conjugated |
| Short name: |
FITC Conjugated, Hamartin/TSC1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Hamartin/TSC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12362 |
| Gene: |
TSC1 |
More about : TSC1 |
| Long gene name: |
tuberous sclerosis 1 |
| Synonyms gene: |
TSC |
| Locus: |
9q34 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF013168 |
| Pubmed identfication: |
9242607 10806479 |
| Havana BLAST/BLAT: |
OTTHUMG00000020844 |
| Locus Specific Databases: |
TSC Mutation Database Tuberous sclerosis database LRG_486 |