| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TRP12 |
| Specificity: |
This antibody reacts specifically with TRP12 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TRPV4 |
| Gene ID: |
59341 |
| Swiss Prot: |
Q9HBA0 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification, Acts as a regulator of intracellular Ca(2+) in synoviocytes, Also activated by low pH, Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism, Increase of intracellular Ca(2+) potentiates currents, Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12, Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers, citrate and phorbol esters, 13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8, Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
OTRPC4 TRP12 VROAC VRL-2 VR-OAC CMT2C |
| Also known as: |
TRP12 Polyclonal Antibody |
| Other name: |
Anti-TRP12 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TRP12 |
| Short name: |
Anti-TRP12 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TRP12 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18083 |
| Gene: |
TRPV4 |
More about : TRPV4 |
| Long gene name: |
transient receptor potential cation channel subfamily V member 4 |
| Synonyms gene name: |
member 4 , subfamily V, transient receptor potential cation channel |
| Synonyms name: |
osmosensitive transient receptor potential channel 4 |
| Locus: |
12q24, 11 |
| Discovery year: |
2002-01-29 |
| GenBank acession: |
AF263523 |
| Entrez gene record: |
59341 |
| Pubmed identfication: |
11025659 11081638 16382100 20037587 |
| RefSeq identity: |
NM_021625 |
| Classification: |
Ankyrin repeat domain containing Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000169277 |
| Locus Specific Databases: |
LRG_372 |