| Long name: |
TRP12 Primary Polyclonal Antibody |
| Also known as: |
TRP12 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TRP12 |
| Specificity: |
This is a highly specific antibody against TRP12 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
310-360/871 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRPV4 |
| Gene ID number: |
59341 |
| Swiss Prot: |
Q9HBA0 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification, Acts as a regulator of intracellular Ca(2+) in synoviocytes, Also activated by low pH, Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism, Increase of intracellular Ca(2+) potentiates currents, Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12, Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers, citrate and phorbol esters, 13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8, Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BCYM3, CMT2C, HMSN2C, OTRPC4, Osm-9-like TRP channel 4, SPSMA, SSQTL1, TRP12, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, TrpV4, VR-OAC, VRL-2, VRL2, VROAC, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, SMAL |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TRP12 |
| Short name: |
TRP12 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRP12 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18083 |
| Gene: |
TRPV4 |
More about : TRPV4 |
| Long gene name: |
transient receptor potential cation channel subfamily V member 4 |
| Synonyms gene name: |
member 4 , subfamily V, transient receptor potential cation channel |
| Synonyms: |
OTRPC4 TRP12 VROAC VRL-2 VR-OAC CMT2C |
| Synonyms name: |
osmosensitive transient receptor potential channel 4 |
| Locus: |
12q24, 11 |
| Discovery year: |
2002-01-29 |
| GenBank acession: |
AF263523 |
| Entrez gene record: |
59341 |
| Pubmed identfication: |
11025659 11081638 16382100 20037587 |
| RefSeq identity: |
NM_021625 |
| Classification: |
Ankyrin repeat domain containing Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000169277 |
| Locus Specific Databases: |
LRG_372 |