| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CYLD Ser418 |
| Specificity: |
CYLD (Ser418), This phophorylation site is homologous to that of Ser414 in Mouse and Ser415 in Rat |
| Modification: |
Phosphorylation |
| Modification site: |
Ser418 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human CYLD around the phosphorylation site of Ser418 |
| Gene ID: |
1540 |
| Swiss Prot: |
Q9NQC7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Contributes to the regulation of cell survival, Dispensable for the maturation of intrathymic natural killer cells, Has endodeubiquitinase activity, Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules, Inhibits nuclear translocation of NF-kappa-B, Negative regulator of Wnt signaling, Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity), Plays a role in the regulation of inflammation and the innate immune response, Plays a role in the regulation of microtubule dynamics, Plays an important role in the regulation of pathways leading to NF-kappa-B activation, Required for normal cell cycle progress and normal cytokinesis, and angiogenesis, and thereby contributes to the regulation of cell proliferation, but required for the continued survival of immature natural killer cells, cell migration, cell polarization, proliferation and differentiation via its effects on NF-kappa-B activation, via its effects on NF-kappa-B activation, Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0849 USPL2 |
| Also known as: |
CYLD (Ser418) Polyclonal Antibody |
| Other name: |
Anti-CYLD (Ser418) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CYLD (Ser418) |
| Short name: |
Anti-CYLD (Ser418) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CYLD (Ser418) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2584 |
| Gene: |
CYLD |
More about : CYLD |
| Long gene name: |
CYLD lysine 63 deubiquitinase |
| Synonyms gene: |
CYLD1 |
| Synonyms gene name: |
cylindromatosis (turban tumor syndrome) |
| Synonyms name: |
ubiquitin specific peptidase like 2 |
| Locus: |
16q12, 1 |
| Discovery year: |
1996-12-17 |
| GenBank acession: |
AB020656 |
| Entrez gene record: |
1540 |
| Pubmed identfication: |
7493027 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000173404 |
| Locus Specific Databases: |
LRG_491 |