| Long name: |
FITC Conjugated, CYLD (Ser418) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CYLD Ser418 |
| Specificity: |
This phophorylation site is homologous to that of Ser414 in Mouse and Ser415 in Rat, This is a highly specific antibody against CYLD Ser418 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser418 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
390-440/956 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CYLD around the phosphorylation site of Ser418 |
| Gene ID number: |
1540 |
| Swiss Prot: |
Q9NQC7 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Contributes to the regulation of cell survival, Dispensable for the maturation of intrathymic natural killer cells, Has endodeubiquitinase activity, Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules, Inhibits nuclear translocation of NF-kappa-B, Negative regulator of Wnt signaling, Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity), Plays a role in the regulation of inflammation and the innate immune response, Plays a role in the regulation of microtubule dynamics, Plays an important role in the regulation of pathways leading to NF-kappa-B activation, Required for normal cell cycle progress and normal cytokinesis, and angiogenesis, and thereby contributes to the regulation of cell proliferation, but required for the continued survival of immature natural killer cells, cell migration, cell polarization, proliferation and differentiation via its effects on NF-kappa-B activation, via its effects on NF-kappa-B activation, Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA0849 USPL2 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CYLD (Ser418) Conjugated |
| Short name: |
FITC Conjugated, CYLD (Ser418) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, CYLD (Ser418) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2584 |
| Gene: |
CYLD |
More about : CYLD |
| Long gene name: |
CYLD lysine 63 deubiquitinase |
| Synonyms gene: |
CYLD1 |
| Synonyms gene name: |
cylindromatosis (turban tumor syndrome) |
| Synonyms name: |
ubiquitin specific peptidase like 2 |
| Locus: |
16q12, 1 |
| Discovery year: |
1996-12-17 |
| GenBank acession: |
AB020656 |
| Entrez gene record: |
1540 |
| Pubmed identfication: |
7493027 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000173404 |
| Locus Specific Databases: |
LRG_491 |