| Long name: |
1) Monoclonal Antibody, 3, 6, CYLD (1667CT857 |
| Also known as: |
1) Monoclonal Antibody, 3, 6, CYLD (1667CT857 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CYLD |
| Specificity: |
This is a highly specific antibody against CYLD |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 1667CT857, 3, 6 |
| Source: |
This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD |
| Gene ID number: |
1540 |
| Swiss Prot: |
Q9NQC7 |
| Tested Applications: |
FCM, WB |
| Recommended dilutions: |
WB(1:4000), FC(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Contributes to the regulation of cell survival, Dispensable for the maturation of intrathymic natural killer cells, Has endodeubiquitinase activity, Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491), Inhibits nuclear translocation of NF-kappa-B, Involved in the regulation of ciliogenesis, Negative regulator of Wnt signaling (PubMed:20227366), Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity), Plays a role in the regulation of inflammation and the innate immune response, Plays a role in the regulation of microtubule dynamics, Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691), PubMed:19893491), PubMed:20194890), Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, allowing ciliary basal bodies to migrate and dock to the plasma membrane, and angiogenesis (PubMed:18222923, and thereby contributes to the regulation of cell proliferation, but required for the continued survival of immature natural killer cells, cell migration, cell polarization, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690), this process does not depend on NF-kappa-B activation (By similarity), via its effects on NF-kappa-B activation (PubMed:18636086), Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BRSS, CDMT, CYLD, CYLD1, CYLDI, Deubiquitinating enzyme CYLD, HSPC057, KIAA0849, MFT, MFT1, SBS, TEM, USPL2, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD, EAC |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1) Monoclonal, 3, 6, CYLD (1667CT857 |
| Short name: |
1) Monoclonal Antibody, 3, 6, CYLD (1667CT857 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1) monoclonal (Antibody to), 3, 6, CYLD (1667CT857 |
| Alternative technique: |
antibodies |
| Identity: |
2584 |
| Gene: |
CYLD |
More about : CYLD |
| Long gene name: |
CYLD lysine 63 deubiquitinase |
| Synonyms gene: |
CYLD1 |
| Synonyms gene name: |
cylindromatosis (turban tumor syndrome) |
| Synonyms: |
KIAA0849 USPL2 |
| Synonyms name: |
ubiquitin specific peptidase like 2 |
| Locus: |
16q12, 1 |
| Discovery year: |
1996-12-17 |
| GenBank acession: |
AB020656 |
| Entrez gene record: |
1540 |
| Pubmed identfication: |
7493027 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000173404 |
| Locus Specific Databases: |
LRG_491 |