| Long name: |
CYLD (Ser418) Primary Polyclonal Antibody |
| Also known as: |
CYLD (Ser418) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CYLD Ser418 |
| Specificity: |
This phophorylation site is homologous to that of Ser414 in Mouse and Ser415 in Rat, This is a highly specific antibody against CYLD Ser418 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser418 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
390-440/956 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CYLD around the phosphorylation site of Ser418 |
| Gene ID number: |
1540 |
| Swiss Prot: |
Q9NQC7 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Contributes to the regulation of cell survival, Dispensable for the maturation of intrathymic natural killer cells, Has endodeubiquitinase activity, Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules, Inhibits nuclear translocation of NF-kappa-B, Negative regulator of Wnt signaling, Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity), Plays a role in the regulation of inflammation and the innate immune response, Plays a role in the regulation of microtubule dynamics, Plays an important role in the regulation of pathways leading to NF-kappa-B activation, Required for normal cell cycle progress and normal cytokinesis, and angiogenesis, and thereby contributes to the regulation of cell proliferation, but required for the continued survival of immature natural killer cells, cell migration, cell polarization, proliferation and differentiation via its effects on NF-kappa-B activation, via its effects on NF-kappa-B activation, Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BRSS, CDMT, CYLD, CYLD1, CYLDI, Deubiquitinating enzyme CYLD, HSPC057, KIAA0849, MFT, MFT1, SBS, TEM, USPL2, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD, EAC |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CYLD (Ser418) |
| Short name: |
CYLD (Ser418) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CYLD (Ser418) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2584 |
| Gene: |
CYLD |
More about : CYLD |
| Long gene name: |
CYLD lysine 63 deubiquitinase |
| Synonyms gene: |
CYLD1 |
| Synonyms gene name: |
cylindromatosis (turban tumor syndrome) |
| Synonyms: |
KIAA0849 USPL2 |
| Synonyms name: |
ubiquitin specific peptidase like 2 |
| Locus: |
16q12, 1 |
| Discovery year: |
1996-12-17 |
| GenBank acession: |
AB020656 |
| Entrez gene record: |
1540 |
| Pubmed identfication: |
7493027 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000173404 |
| Locus Specific Databases: |
LRG_491 |