| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
APPBP1 |
| Specificity: |
This antibody reacts specifically with APPBP1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human APPBP1 |
| Gene ID: |
8883 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
APPBP1 is a cell membrane associated protein and functions as the regulatory subunit in a heterodimer with UBA3, APPBP1 is essential for cell cycle progression through the S/M checkpoint, In addition, In fetal tissues APPBP1 is widely expressed and in adult tissues it is expressed throughout the brain, More specifically, The APPBP1/UBA3 complex binds to and activates NEDD8, This suggests that APPBP1 affects a variety of cellular functions, a ubiquitin-like protein involved in signal transduction, cell proliferation and development, it inhibits the entry into S phase and promotes entry into M phase, APPBP1 is a member of the ubiquitin-activating E1 family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ula-1 APP-BP1 |
| Also known as: |
APPBP1 Polyclonal Antibody |
| Other name: |
Anti-APPBP1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
APPBP1 |
| Short name: |
Anti-APPBP1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-APPBP1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
621 |
| Gene: |
NAE1 |
More about : NAE1 |
| Long gene name: |
NEDD8 activating enzyme E1 subunit 1 |
| Synonyms gene: |
APPBP1 |
| Synonyms gene name: |
59kDa , amyloid beta precursor protein binding protein 1 |
| Locus: |
16q22, 1 |
| Discovery year: |
1999-01-13 |
| GenBank acession: |
U50939 |
| Entrez gene record: |
8883 |
| Pubmed identfication: |
8626687 12740388 |
| RefSeq identity: |
NM_003905 |
| Classification: |
Ubiquitin like modifier activating enzymes |
| Havana BLAST/BLAT: |
OTTHUMG00000137513 |