| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CSEN Ser63 |
| Specificity: |
This antibody reacts specifically with CSEN (Ser63) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser63 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Membrane bound |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human CSEN around the phosphorylation site of Ser63 |
| Gene ID: |
30818 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DRE is a regulatory sequence that silences basal transcription and is localized to the promoter region of the gene encoding human prodynorphin, DREAM forms functional homotetramers that are required for the interaction with the DRE, DREAM has been shown to inhibit transcription of other proteins containing DRE-like motifs, DREAM transcripts are detected in brain, This association is highly influenced by calcium, an opioid peptide involved in memory acquisition and pain, and it is expressed as a nuclear protein, as an increase in Ca2+ directly inhibits DREAM binding and thereby blocks the repressor activity of DREAM, including the gene encoding for the AP-1 transcription factor c-Fos, suggesting that DREAM may influence a wide variety of cellular genes, thymus and thyroid gland, CSEN is a Ca2+-regulated transcriptional repressor that specifically binds to the downstream regulatory elements (DRE) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DREAM KCHIP3 |
| Also known as: |
CSEN (Ser63) Polyclonal Antibody |
| Other name: |
Anti-CSEN (Ser63) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CSEN (Ser63) |
| Short name: |
Anti-CSEN (Ser63) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CSEN (Ser63) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
15523 |
| Gene: |
KCNIP3 |
More about : KCNIP3 |
| Long gene name: |
potassium voltage-gated channel interacting protein 3 |
| Synonyms gene: |
CSEN |
| Synonyms gene name: |
EF hand transcription factor Kv channel interacting protein 3, calsenilin, calsenilin , presenilin-binding protein |
| Synonyms name: |
calsenilin |
| Locus: |
2q11, 1 |
| Discovery year: |
2001-05-24 |
| GenBank acession: |
AF199599 |
| Entrez gene record: |
30818 |
| Pubmed identfication: |
9771752 10078534 |
| RefSeq identity: |
NM_013434 |
| Classification: |
Potassium voltage-gated channel regulatory subunits EF-hand domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130392 |