| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PI3 Kinase p110 delta |
| Specificity: |
This antibody reacts specifically with PI3 Kinase p110 delta |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PI3 Kinase p110 delta |
| Gene ID: |
5293 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues, CCR7 and S1PR1 and antigen dependent recruitment of T-cells, Contributes to T-helper cell expansion and differentiation, Have a role in NK cell maturation and cytokine production, Have important roles in mast-cell development and mast cell mediated allergic response, Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P), Involved in stem cell factor (SCF)-mediated proliferation, Involved in the antigen presentation function of B-cells, Mediates B-cell proliferation response to anti-IgM, Mediates TCR signaling events at the immune synapse, Mediates immune responses, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Participates in NK cell receptor activation, Plays a role in B-cell development, Promotes cytokine production in response to TLR4 and TLR9, Required for B-cell receptor (BCR) signaling, Required for T-cell migration mediated by homing receptors SELL/CD62L, Required for T-cell receptor (TCR) signaling, Required for antibody class switch mediated by TLR9, Required for proliferation, Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation, Together with PIK3CG is involved in neutrophil chemotaxis and extravasation, Together with PIK3CG participates in T-cell development, Together with PIK3CG participates in neutrophil respiratory burst, activating signaling cascades involved in cell growth, adhesion and migration, and function, anti-CD40 and IL4 stimulation, effector and memory T-cells, including AKT1 and PDPK1, migration, motility and morphology, proliferation, proliferation, signaling and cytokine production of naive, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ESI SKALP ELAFIN WAP3 WFDC14 cementoin |
| Also known as: |
PI3 Kinase p110 delta antibody |
| Other name: |
Anti-PI3 Kinase p110 delta |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
PI3 Kinase p110 delta |
| Short name: |
Fluor 594, Anti-PI3 Kinase p110 delta |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PI3 phosphorylation catalyst p110 delta |
| Identity: |
8947 |
| Gene: |
PI3 |
More about : PI3 |
| Long gene name: |
peptidase inhibitor 3 |
| Synonyms gene name: |
protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3 |
| Synonyms name: |
skin-derived antileukoproteinase trappin-2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1993-07-27 |
| GenBank acession: |
D13156 |
| Entrez gene record: |
5266 |
| Pubmed identfication: |
8287685 12206714 |
| RefSeq identity: |
NM_002638 |
| Classification: |
WAP four-disulfide core domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032567 |