| Long name: |
Cy5 Conjugated, PI3 Kinase p110 beta(Ser1070) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PI3 Kinase p110 beta Ser1070 |
| Specificity: |
This phosphorylation site is homologous to that of Ser1064 in Mouse and Ser1070 in Rat, This is a highly specific antibody against PI3 Kinase p110 beta Ser1070 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser1070 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1020-1070/1070 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070 |
| Gene ID number: |
5291 |
| Swiss Prot: |
P42338 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Has a role in cell survival, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, Involved in the early stage of autophagosome formation, May act as a scaffold, May also act downstream receptor tyrosine kinases, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, May have a role in cell migration, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, Mediator of oncogenic signal in cell lines lacking PTEN, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Plays a role in platelet activation signaling triggered by GPCRs, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Required for the growth of ERBB2 and RAS driven tumors, Required in different signaling pathways for stable platelet adhesion and aggregation, The lipid kinase activity is necessary for its role in oncogenic transformation, activating signaling cascades involved in cell growth, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, and lysophosphatidic acid, including AKT1 and PDPK1, independently of its lipid kinase activity to positively regulate autophagy, motility and morphology, proliferation, sphingosine 1-phosphate, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
625, 650nm/670nm |
| Synonyms: |
ESI SKALP ELAFIN WAP3 WFDC14 cementoin |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PI3 Kinase p110 beta(Ser1070) Conjugated |
| Short name: |
Conjugated, PI3 Kinase p110 beta(Ser1070) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy5 |
| Alternative name: |
cyanine 5 coupled, PI3 phosphorylation catalyst p110 b(Ser1070) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8947 |
| Gene: |
PI3 |
More about : PI3 |
| Long gene name: |
peptidase inhibitor 3 |
| Synonyms gene name: |
protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3 |
| Synonyms name: |
skin-derived antileukoproteinase trappin-2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1993-07-27 |
| GenBank acession: |
D13156 |
| Entrez gene record: |
5266 |
| Pubmed identfication: |
8287685 12206714 |
| RefSeq identity: |
NM_002638 |
| Classification: |
WAP four-disulfide core domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032567 |