| Long name: |
ALEXA FLUOR 647 Conjugated, PI3 Kinase p110 beta(Ser1070) Antibody |
| Also known as: |
Anti-PI3 Kinase p110 beta Ser1070 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PI3 Kinase p110 beta Ser1070 |
| Specificity: |
This is a highly specific antibody against PI3 Kinase p110 beta Ser1070 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser1070 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1020-1070/1070 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070 |
| Gene ID Number: |
5291 |
| Swiss Prot: |
P42338 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Has a role in cell survival, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, Involved in the early stage of autophagosome formation, May act as a scaffold, May also act downstream receptor tyrosine kinases, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, May have a role in cell migration, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, Mediator of oncogenic signal in cell lines lacking PTEN, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Plays a role in platelet activation signaling triggered by GPCRs, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Required for the growth of ERBB2 and RAS driven tumors, Required in different signaling pathways for stable platelet adhesion and aggregation, The lipid kinase activity is necessary for its role in oncogenic transformation, activating signaling cascades involved in cell growth, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, and lysophosphatidic acid, including AKT1 and PDPK1, independently of its lipid kinase activity to positively regulate autophagy, motility and morphology, proliferation, sphingosine 1-phosphate, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
ESI SKALP ELAFIN WAP3 WFDC14 cementoin |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the PI3 Kinase p110 beta(Ser1070) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
PI3 Kinase p110 beta(Ser1070) |
| Short name: |
PI3 Kinase p110 beta(Ser1070) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, PI3 phosphorylation catalyst p110 b(Ser1070) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8947 |
| Gene: |
PI3 |
More about : PI3 |
| Long gene name: |
peptidase inhibitor 3 |
| Synonyms gene name: |
protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3 |
| Synonyms name: |
skin-derived antileukoproteinase trappin-2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1993-07-27 |
| GenBank acession: |
D13156 |
| Entrez gene record: |
5266 |
| Pubmed identfication: |
8287685 12206714 |
| RefSeq identity: |
NM_002638 |
| Classification: |
WAP four-disulfide core domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032567 |